As a direct result of their studies a patent was granted which resulted in a test to identify patients that were likely to develop recurrent miscarriages or thrombosis. Professor Krilis and his team also, in collaboration with overseas institutes such as Harvard Medical School, are at the forefront of basic research in mast cells; cells that are involved in the cause of asthma and other related conditions.
(Professor Krilis' laboratory has published over 170 scientific papers and these have been quoted by other investigators 5,355 times which is a highly cited laboratory.)
Shi T, Iverson M, Qi JC, Cockerill KA, Linnik MD, Konecny P, Krilis SA. B2 –Glycoprotein 1 binds factor XI and inhibits its activation by thrombin and factor X11a: loss of inhibition by clipped B2-glycoprotein 1. PNAS 2004 101(11); 3939-44.
Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RHWM, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Rincani A. Vlachoyiannopoulos RG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis; 2006, 4:295-306.
Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA. The diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor 2. Journal of Biological Chemistry 2008 283(3); 1610-1621.
McNeill HP, Simpson RJ, Chesterman CJ, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor or coagulation: B2-Glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990 Vol 87;4120-24.
